Formic Acid → HCID 86607919, compound

Participants

Reaction Steps

According to the procedure of Example 53, Step 2,using crude methyl (1S,2R)-2-{benzyl[(1R)-1-phenylethyl]amino}-1-(hydroxymethyl)cyclopentanecarboxylate (800 mg), 4.4% formic acid in methanol (50 mL) and 10% Pd/C (421 mg), methyl (1S,2R)-2-amino-1-(hydroxymethyl)cyclopentanecarboxylate was obtained (404 mg, 1.93 mmol) as a colorless solid. 1H NMR (400 MHz, MeOD) δ ppm 1.76-1.82 (m, 2H) 1.84-1.92 (m, 1H) 2.09-2.18 (m, 1H) 2.20-2.30 (m, 1H) 3.58-3.68 (m, 2H) 3.81 (s, 3H) 3.97-4.02 (m, 1H).

Provenance & Evidence