Trifluoroacetic acid → HCID 11856681, compound

Participants

Reaction Steps

(3R,4R)-N-tert-Butoxy-3-hydroxy-4-(4-((2-methylquinolin-4-yl) methoxy)phenylsulfonamido)piperidine-3-carboxamide trifluoroacetic acid salt (Example 46, Step 8) was treated with neat trifluoroacetic acid (3 mL) at 45° C. for 5 days. After removal of trifluoroacetic acid, the residue was purified using preparative HPLC, eluting with a gradient of 10-30% acetonitrile with triethylamine (10 min) to yield 17.2 mg (22%) of (3R,4R)-N,3-dihydroxy-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]piperidine-3-carboxamide as white powder. HRMS: calcd for C23H26N4O6S+H+, 487.16458; found (ESI-FTMS, [M+H]1+), 487.1646

Provenance & Evidence