Diisopropylethylamine → HCID 73128480, compound

Participants

Reaction Steps

To a solution of racemic (1S,2R)-2-methyl-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylate (0.075 g) in DMF (0.8 mL) was added BOP (0.1 g, 1.3 eq), diisopropylethylamine (0.122 mL, 4 eq) and hydroxylamine hydrochloride (0.024 g, 2 eq). The reaction was stirred for 8 h and purified by direct injection onto an HPLC to afford racemic (1S,2R)-N-hydroxy-2-methyl -2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxamide (0.03 g, 40%) as a white powder. MS: 484.1 (M+H)+

Provenance & Evidence