trans-2-Aminocyclohexanecarboxylic acid → trans-2-[({4-[(2-Methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid

Participants

Reaction Steps

According to the procedure of Example 10, Step 1, the reaction of 487 mg (3.4 mmol) of trans-2-amino-1-cyclohexanecarboxylic acid with 1.31 g of 4-(2-methyl-quinolin-4-ylmethoxy) -benzenesulfonyl chloride hydrochloride provided 382.7 mg of trans-2-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxylic acid in 25% yield. MS: 455.1 (M+H)+

Provenance & Evidence