HCID 17606475, compound → HCID 11535601, compound

HRID 736917Notes

Reaction equation

HRID 736917 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[C:15]([NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)([CH3:18])([CH3:16])[CH3:17]

Participants

4

Reactant 1

HCID 17606475HCID 17606475, compound

Product 1

HCID 11535601HCID 11535601, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.5 g 10% Pd/C were added to a solution of 13.9 g (56.0 mmol) (1-benzyl-piperidin-4-yl)-tert-butyl-amine in 140 mL MeOH and the reaction mixture was hydrogenated at RT until the theoretical uptake of H2 had been achieved (2 h). After the catalyst had been removed by suction filtering and the solvent was eliminated, the desired product was obtained, which was farther reacted without being purified.

Workup

  1. customwas hydrogenated at RT until the theoretical uptake of H2
  2. custom(2 h)
  3. customAfter the catalyst had been removed by suction
  4. filtrationfiltering

Sources & evidence

ORD record
ord-620bc9728b214c4d8b820eff2aaa6619
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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