Triethylamine → HCID 12094440, compound

Participants

Reaction Steps

A mixture of 15.4 g (40.3 mmol) of 4-tert. butyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinate, 7.4 g (40.3 mmol) of (1-methyl-4-piperidin-4-yl)-piperazine, 5.45 g (40.3 mmol) of HOBt, 12.94 g (40.3 mmol) of TBTU, 11.77 mL (85.0 mmol) of triethylamine and 400 mL of THF was stirred for 12 h at RT. Then the mixture was evaporated down i. vac. and the residue remaining was distributed between EtOAc and NaHCO3 solution. The org. phase was separated off, dried and evaporated down i. vac. The residue obtained was purified by chromatography on aluminium oxide. The desired product was obtained in the form of a yellow oil.

Provenance & Evidence