反应详情

3.13 g (78.25 mmol) of NaOH, dissolved in 300 mL water, were added to a solution of 10.00 g (15.65 mmol) of diethyl 2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-{2-oxo-2-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-ethyl}-malonate in 600 mL EtOH and the mixture was refluxed for 4 h. EtOH was evaporated off i. vac., the reaction mixture was acidified to pH 1 with conc. HCl and 1 hour at RT. The precipitate formed was filtered off, washed with water and dried i. vac.

1. temperaturethe mixture was refluxed for 4 h
2. customEtOH was evaporated off i
3. customwas acidified to pH 1 with conc. HCl and 1 hour at RT
4. customThe precipitate formed
5. filtrationwas filtered off
6. washwashed with water
7. customdried i