Hydrochloric Acid → HCID 9987693, compound

Participants

Reaction Steps

A solution of 20.1 mg (0.47 mmol) lithium hydroxide hydrate in 10 mL water was added to a solution of 250 mg (0.32 mmol) ethyl[1′-((R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carbonyl]-amino}-propionyl)-4,4′-bipiperidinyl-1-yl]-acetate (Example 7.5) in 5 mL THF and the reaction mixture was stirred for 2 h at RT. 0.5 mL 1 M HCl were added, the substance precipitated was filtered off and dried at 50° C. The crude product was purified by HPLC.

Provenance & Evidence