Sodium Hydroxide → 3-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carbonyl]-amino}-propionic Acid

Participants

Reaction Steps

45 mL of 1 M NaOH were added to a solution of 13.00 g (22.34 mmol) of ethyl 3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carbonyl]-amino}-propionate in 100 mL EtOH and the mixture was stirred, for 16 h at RT. EtOH was evaporated off i. vac., 45 mL of 1M HCl were added and the mixture was stirred for 15 min. The precipitate formed was filtered off, washed with water and dried i. vac. at 75° C.

Provenance & Evidence