HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736939Generated: October 29, 2026
Hydrochloric Acid → 4-Amino-3-(trifluoromethyl)benzoic acid
https://huagongshe.com/reaction/736939
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-amino-3-(trifluoromethyl)benzoate | HCID 25067387 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Amino-3-(trifluoromethyl)benzoic acid | HCID 3254286 | — |
Reaction Steps
At RT a solution of 153 g (0.66 mol) ethyl 4-amino-3-trifluoromethyl-benzoate in 350 mL EtOH was added to a solution of 100 g (2.5 mol) NaOH in 250 mL water and the reaction mixture was stirred for 2 h at 45° C. EtOH was eliminated i. vac., the remaining aqueous solution was acidified with conc. HCl, the precipitated product was suction filtered, washed with water and dried in the air.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07595312B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-51a0e86014c449ceadde1965ecde97c5 |
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| Source note | uspto-grants-2009_09 |
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