HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68589918, compound → 4-Amino-3-chloro-5-(trifluoromethyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68589918 | HCID 68589918 | — |
| Reactant | (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoic acid | HCID 68591515 | — |
| Reactant | 1-methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinate | HCID 86604295 | — |
| Reactant | 1-Methyl 2-[1-(4-amino-3-bromo-5-trifluoromethyl-phenyl)-meth-(e)-ylidene]-succinate | HCID 131727647 | — |
| Product | 4-Amino-3-chloro-5-(trifluoromethyl)benzaldehyde | HCID 13020473 | — |
Reaction Steps
Analogously to the sequence described in 9f to 9i, 1-methyl (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-succinate and (S)-2-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoic acid were able to be obtained from 4-amino-3-chloro-5-trifluoromethyl-benzaldehyde (see Example 1b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595312B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f782fab6c3da45fca7dd991b9aaf1026 |
| Source note | uspto-grants-2009_09 |