HCID 10417675, compound → HCID 57848519, compound

Participants

Reaction Steps

100 mg 10% Pd/C were added to a solution of 150 mg (0.2 mmol) (S)-2-(4-amino-3-bromo-5-trifluoromethyl-benzyl)-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butan-1,4-dione in 20 mL MeOH and the reaction mixture was hydrogenated at 50 psi H2 for 3 h at RT. The catalyst was suction filtered, the solvent was evaporated down i.vac., the residue was combined with 5% K2CO3 solution and EtOAc, the organic phase was separated off and evaporated down i.vac. The residue was triturated with diisopropylether and suction filtered.

Provenance & Evidence