Hydrochloric Acid → HCID 86604296, compound

Participants

Reaction Steps

A solution of 0.72 g (16.75 mmol) lithium hydroxide hydrate in 30 mL water was added to a solution of 6.7 g (11.16 mmol) methyl (S)-2-(4-amino-3,5-bis-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-butanoate in 50 mL THF at RT and the reaction mixture was stirred for 5 h at RT. The THF was eliminated i. vac., the aqueous solution cooled to 10° C. and adjusted to pH 1 with conc. HCl, during which time the product was precipitated. This was suction filtered and dried at 65° C. The dried substance was combined with 300 mL diisopropylether, stirred overnight, suction filtered, washed with diisopropylether and dried.

Provenance & Evidence