Ethyl(4-piperidin-4-yl-piperazin-1-yl)-acetate → [4-(1-{2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyryl}-piperidin-4-yl)-piperazin-1-yl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Ethyl(4-piperidin-4-yl-piperazin-1-yl)-acetate	HCID 57848475	—
Reactant	2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid	HCID 68592393	—
Product	[4-(1-{2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butyryl}-piperidin-4-yl)-piperazin-1-yl]-acetic acid	HCID 57848346	—

Reaction Steps

Prepared analogously to Example 16.4 from 105 mg (0.2 mmol) 2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid and 51 mg (0.2 mmol) ethyl(4-piperidin-4-yl-piperazin-1-yl)-acetate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595312B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-e53a0caaff0c4ef5be0737b804b54553
Source note	uspto-grants-2009_09