HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(6-Methoxy-cyclohex-1-enyl)-1H-indole → 3-(2-Methoxy-cyclohexyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(6-Methoxy-cyclohex-1-enyl)-1H-indole | HCID 58975073 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(2-Methoxy-cyclohexyl)-1H-indole | HCID 58975094 | 63% |
Reaction Steps
Treat 3-(6-methoxy-cyclohex-1-enyl)-1H-indole (200 mg, 0.879 mmol) with 10% Pd/C (40 mg) in EtOAc under atmospheric hydrogenation conditions for 1.5 hours. Filter resulting solution over Celite to remove catalyst. Concentrate crude on rotovap and purify on silica gel chromatography to give 3-(2-Methoxy-cyclohexyl)-1H-indole (127 mg, 63% yield). Mass Spectrum (m/e): 230.03 (MH+), 228.14 (M−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-683d20d846bf496d957543d5f33f089d |
| Source note | uspto-grants-2009_09 |