HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 3-(4-Methylpiperazin-1-YL)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 3-Morpholin-4-yl-1H-indole | HCID 12530833 | — |
| Reactant | 3-(4-Methyl-piperazin-1-yl)-1-triisopropylsilanyl-1H-indole | HCID 58975109 | — |
| Product | 3-(4-Methylpiperazin-1-YL)-1H-indole | HCID 53414691 | — |
Reaction Steps
Following a method similar to 3-morpholin-4-yl-1H-indole using 3-(4-Methyl-piperazin-1-yl)-1-triisopropylsilanyl-1H-indole (0.35 g, 0.94 mmol) and 1N solution of tetrabutylammonium fluoride (1.40 mL) to prepare the title compound. Purify by flash chromatography using 2 to 12% methanol in dichloromethane to give the title compound (0.12 g 60%). MS (ES) 216.1 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-1584515b0c00488caea2f74df2553798 |
| Source note | uspto-grants-2009_09 |