HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 3-(4-piperidyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 3-Morpholin-4-yl-1H-indole | HCID 12530833 | — |
| Reactant | 3-Piperidin-1-yl-1-triisopropylsilanyl-1H-indole | HCID 58974986 | — |
| Product | 3-(4-piperidyl)-1H-indole | HCID 87092 | 71.3% |
Reaction Steps
Following a method similar to 3-morpholin-4-yl-1H-indole using 3-Piperidin-1-yl-1-triisopropylsilanyl-1H-indole (0.30 g, 0.84 mmol) and 1N solution of tetrabutylammonium fluoride (1.30 mL). Purify by flash chromatography using 20 to 50% of EtOAc in hexanes to give the title compound (0.12 g 71%). MS (ES) 201.1 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-995f1ba85bb046fda717dae1cd01f769 |
| Source note | uspto-grants-2009_09 |