HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2-Fluoropyridin-4-yl)methanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Cyano-2-fluoropyridine | HCID 12002587 | — |
| Reactant | (2-Fluoropyridin-3-yl)methanamine hydrochloride | HCID 67023208 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | (2-Fluoropyridin-4-yl)methanamine hydrochloride | HCID 66524242 | 50% |
Reaction Steps
Following a method similar to C-(2-Fluoro-pyridin-3-yl)-methylamine hydrochloride, using 2-fluoro-isonicotinonitrile (0.65 g, 5.3 mmol), concentrated HCl (1.2 mL), and 5% Pd/C (1.2 g) to give the title compound (0.43 g, 50%). MS (ES) 127.1 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-9207d44fa4224198aa85397316b293bb |
| Source note | uspto-grants-2009_09 |