HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-[4-(Trifluoromethyl)pyridin-3-yl]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(trifluoromethyl)nicotinonitrile | HCID 2736743 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[4-(Trifluoromethyl)pyridin-3-yl]methanamine | HCID 3523817 | 98% |
Reaction Steps
Add Raney nickel (0.5 g) to a solution of 4-trifluoromethyl-nicotinonitrile (1.0 g, 5.8 mmol) in ethanol saturated with ammonia (20.0 mL) and shake under hydrogen at 500 psi for 1 hour. Filter reaction, concentrate the filtrate, and dry the solid obtained to give the title compound (1.0 g, 98%). MS (ES) 177.0 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-a785a0097be4416db854c3a87708f53f |
| Source note | uspto-grants-2009_09 |