Hydrazine → HCID 178419918, compound

HRID 737017Notes

Reaction equation

HRID 737017 reaction equation
[CH:1]1([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2F)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:15][NH2:16]>>[CH:1]1([C:6]2[C:8]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:16][N:15]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 13771614Cyclopentyl(2-fluorophenyl)methanone

Product 1

HCID 178419918HCID 178419918, compoundYield 89%

Conditions

Temperature
130 °C

Procedure

Dissolve Cyclopentyl-(2-fluoro-phenyl)-methanone (2.5 g 13.005 mmoles) in hydrazine (20 ml) heat to 130° C. for 72 hrs. Cool mixture to 0° C. Filter the precipitate and wash with cold water to give the title compound: 2.171 g (yield=89%) MS ES+ 187.12:MSES− 185.22.

Workup

  1. temperatureCool mixture to 0° C
  2. filtrationFilter the precipitate
  3. washwash with cold water

Sources & evidence

ORD record
ord-1d003964e5414a7487906549a97d0f56
Source dataset
uspto-grants-2009_09
Patent number
US07595339B2

Reaction notes

Loading…