4-Aminomethyltetrahydropyran → HCID 58975095, compound

HRID 737054Notes

Reaction equation

[F:1][C:2]1([F:34])[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([S:16]([C:19]3[CH:33]=[CH:32][C:22]([C:23]([NH:25]C4CCOCC4)=[O:24])=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:8]=2)[CH2:3]1.[O:35]1[CH2:40][CH2:39][CH:38]([CH2:41]N)[CH2:37][CH2:36]1>>[F:1][C:2]1([F:34])[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([S:16]([C:19]3[CH:20]=[CH:21][C:22]([C:23]([NH:25][CH2:41][CH:38]4[CH2:39][CH2:40][O:35][CH2:36][CH2:37]4)=[O:24])=[CH:32][CH:33]=3)(=[O:17])=[O:18])[CH:8]=2)[CH2:3]1

Participants

Reactant 2

HCID 27732104-Aminomethyltetrahydropyran

HCID 58975123HCID 58975123, compound

Product 1

HCID 58975095HCID 58975095, compoundYield 100%

Procedure

Using a similar procedure as for 4-[3-(3,3-Difluoro-cyclopentyl)-indole-1-sulfonyl]-N-(tetrahydro-pyran-4-yl)-benzamide using C-(Tetrahydro-pyran-4-yl)-methylamine in place of Tetrahydro-pyran-4-ylamine to give 4-[3-(3,3-Difluoro-cyclopentyl)-indole-1-sulfonyl]-N-(tetrahydro-pyran-4-ylmethyl)-benzamide (280 mg, 100% yield). Mass Spectrum (m/e): 503.98 (MH+).

Sources & evidence

ORD record: ord-a517af5d307145cb8793396cba640e32
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595339B2

Reaction notes

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