HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-{[4-(3-Phenyl-indole-1-sulfonyl)-benzoylamino]-methyl}-N,N-dimethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 4-{[4-(3-Phenyl-indole-1-sulfonyl)-benzoylamino]-methyl}-benzoic acid | HCID 58975104 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-{[4-(3-Phenyl-indole-1-sulfonyl)-benzoylamino]-methyl}-N,N-dimethyl-benzamide | HCID 58975151 | 15.2% |
Reaction Steps
Combine 4-{[4-(3-Phenyl-indole-1-sulfonyl)-benzoylamino]-methyl}-benzoic acid (0.489 mmole) with dimethylamine (0.587 mmole), and EDC (0.733 mmole) in 5 ml of dichloromethane and stir for 15 hrs. Dilute □eaction and wash with 1 N HCl. Dry organic layer over MgSO4 and concentrate. Purify the residue via column chromatography with a mixture of ethyl acetate and dichloromethane to isolate 0.040 g (15.2%) of the title compound: MSES+ 537.95; MSES− 536.08.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595339B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-4531892da52a48daaf5083bb9cc09852 |
| Source note | uspto-grants-2009_09 |