Sodium cyanoborohydride → HCID 58975187, compound

Participants

Reaction Conditions

Reaction Steps

Add N-(4-Fluoro-benzyl)-4-(3-methyl-indole-1-sulfonyl)-benzamide (0.106 g, 0.25 mmol) portionwise to a stirring mixture of NaCNBH3 (0.074 g, 1.2 mmol, in TFA (5.0 mL) at 0 to 5° C. under N2. Stir the mixture for 15 minutes at 0-5° C., allow to warm to ambient temperature and stir for 1 h. add NaCNBH3 (0.074 g, 1.2 mmol) and stir the reaction is for 2 h dilute with H2O (13.0 mL) and work up as described in the above example. Chromatograph and elute with EtOAc-hexane (0-50%) to give 0.075 g of the title compound: Mass spectrum (m/e) (M+H) 425.1335; found 425.1341.

Provenance & Evidence