HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(3-Bromo-benzyl)-2-phenyl-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromobenzyl bromide | HCID 69979 | — |
| Reactant | 2-Phenylmorpholine | HCID 91101 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(3-Bromo-benzyl)-2-phenyl-morpholine | HCID 57849495 | 65% |
Reaction Steps
1.877 g of 3-Bromobenzyl bromide and 1 g of 2-Phenyl-morpholine in 15 mL of acetonitrile were stirred at room temperature and 2.076 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification by flash chromatography afforded 1.073 g of product. 65% yield ES MS m/z 332
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595397B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-d683687a9ee24236882084116cd19dda |
| Source note | uspto-grants-2009_09 |