4-Bromobenzoic acid → HCID 16894700, compound

Participants

Reaction Steps

5 g of p-Bromobenzoic acid, 4.966 g 3-Phenylmorpholine HCl, 5.245 g EDC, 3.696 g HOBt and 4.766 mL Hunig's Base in 25 mL DMF was stirred at room temperature overnight. The reaction was diluted with water and extracted with ethyl acetate. The organic layers were combined, washed with 1N HCl, aqueous saturated sodium bicarbonate solution and brine. The organics were concentrated in vacuo and purified by flash chromatography to afford product. Wt: 1.335 g, 77% yield. ES MS m/z 346/348

Provenance & Evidence