Ethanolamine → HCID 22167626, compound

HRID 737101Notes

Reaction equation

HRID 737101 reaction equation
[O:1]1[CH2:11][CH:2]1[CH2:3][C:4]12O[CH:5]1[CH:6]=[CH:7][CH:8]=[CH:9]2.[CH2:12]([CH2:14][NH2:15])[OH:13]>O>[OH:13][CH2:12][CH2:14][NH:15][CH2:11][CH:2]([OH:1])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86614311HCID 86614311, compound

Product 1

HCID 22167626HCID 22167626, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The above compound could be made in the same manner as Example 1 using the appropriate epoxide. 1 equivalent of (2,3-Epoxypropyl)benzene oxide and 4 eq. ethanol amine could be stirred at room temperature overnight. The solution could be poured into water and the water is extracted with dichloromethane. The combined dichloromethane layers could be washed with brine and concentrated.

Workup

  1. extractionthe water is extracted with dichloromethane
  2. washThe combined dichloromethane layers could be washed with brine
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-9f979ba53cce411a94cfe0a856685870
Source dataset
uspto-grants-2009_09
Patent number
US07595397B2

Reaction notes

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