Methyl Isocyanate → HCID 57849556, compound

HRID 737120Notes

Reaction equation

HRID 737120 reaction equation
[C:1]1([CH:7]2[NH:12][CH2:11][CH2:10][N:9]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[Cl:26])=[CH:16][CH:15]=3)[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:27][N:28]=[C:29]=[O:30]>ClCCl>[CH3:27][NH:28][C:29]([N:12]1[CH2:11][CH2:10][N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[Cl:26])=[CH:16][CH:15]=2)[CH2:8][CH:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:30]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 57849503HCID 57849503, compound

Product 1

HCID 57849556HCID 57849556, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound could be made in the following manner: 100 mg of 3-phenyl-1-(2′-chloro-biphenyl-4-ylmethyl)-piperazine would be dissolved in dichloromethane, 1.1 equiv. methylisocyanate would be added. The reaction would be stirred at room temperature under nitrogen overnight. Aminomethylpolystyrene (loading 1.6 mmol/g) could be added and the reaction would be shaken for further 6 h. The polymer could be separated by filtration and rinsed with dichloromethane. The filtrate could be concentrated in vacuo to afford the title compound.

Workup

  1. customThe reaction
  2. additionAminomethylpolystyrene (loading 1.6 mmol/g) could be added
  3. customthe reaction
  4. stirringwould be shaken for further 6 h
  5. customThe polymer could be separated by filtration
  6. washrinsed with dichloromethane
  7. concentrationThe filtrate could be concentrated in vacuo

Sources & evidence

ORD record
ord-1536d340396c4525addc783e08fba417
Source dataset
uspto-grants-2009_09
Patent number
US07595397B2

Reaction notes

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