反应详情

400 mg (0.88 mmol) of 2-[4-(4-Nitro-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester was dissolved in 30 mL of 1:1 mixture of EtOH/EtOAc. To this solution was added SnCl2 (0.7 g, 3.1 mmol). Reaction mixture was heated under reflux for 5 hours. After 5 hours reaction mixture was cooled to room temperature and evaporated. It was redissolved in EtOAc (150 mL) and washed using sat. K2CO3. Organic phase was isolated, washed using brine and water and evaporated to dryness to give Compound 5050. MS: 422.1 (M+H+).

1. customReaction mixture
2. temperaturewas heated
3. temperatureunder reflux for 5 hours
4. customAfter 5 hours reaction mixture
5. customevaporated
6. dissolutionIt was redissolved in EtOAc (150 mL)
7. washwashed
8. customOrganic phase was isolated
9. washwashed
10. customevaporated to dryness