反应详情

0.47 g (6.2 mmol) of thiourea and NaOAc (1.5 g, 6.2 mmol) were combined in 35 mL of ethanol. To this suspension was added 4-(2-bromo-acetyl)-benzoic acid (1.5 g, 6.2 mmol). Reaction mixture was stirred at room temperature overnight. It was evaporated to dryness to yield 4-(2-amino-thiazol-4-yl)-benzoic acid which was used in the next step without any further purification. MS: 221.0 (M+H+).

1. customReaction mixture
2. customIt was evaporated to dryness