Diisopropylethylamine → HCID 76582850, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Benzyloxycarbonyl-L-proline	HCID 101987	—
Reactant	5-(4-Methoxy-benzyl)-thiazol-2-ylamine	HCID 3133052	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 76582850	HCID 76582850	—

Reaction Steps

A mixture of Z-Pro-OH (0.96 g, 3.84 mmol), HATU (1.46 g, 3.84 mmol), and DIEA (0.094 mL, 5.4 mmol) in DMF (30 mL) was stirred at room temperature for 1 hour. 1 mL of this solution was added to 10 mg of 5-(4-Methoxy-benzyl)-thiazol-2-ylamine and reaction mixture stirred at room temperature overnight. The resulting mixture was diluted with DMF (5 mL) and water (0.5 mL) and purified using reverse phase HPLC to furnish the corresponding product. MS: 452.1 (M+H+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07595398B2
Source dataset	uspto-grants-2009_09
ORD ID	ord-5a444346fb17426580dbd08f0670e369
Source note	uspto-grants-2009_09