HCID 59140918, compound → HCID 57849778, compound

Participants

Reaction Steps

3-(4-{2-[(1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-thiazol-4-yl}-benzoylamino)-piperidine-1-carboxylic acid tert butyl ester (Compound 5336, Example 336, 100 mg, 0.16 mmol) was dissolved in 4 mL of 1:1 solution of CH2Cl2/TFA and stirred for 1.5 at room temperature. Reaction mixture was evaporated under reduced pressure to give pure desired product. MS: 534.2(M+H+); H1 NMR (MeOH-d4): δ(ppm) (HCl salt)12.47 (s, 1H), 9.52 (s, 1H), 8.64 (s, 1H), 7.95 (m, 5H), 7.50 (br s, 2H), 7.08 (d, 2H), 5.03 (m, 2H), 4.49 (m, 1H), 4.12 (m, 1H), 3.68-2.96 (m, 6H), 2.28 (m, 1H), 1.90 (m, 8H).

Provenance & Evidence