HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Acetate → 5-(2-Amino-thiazol-4-yl)-furan-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Methyl 5-(2-bromoacetyl)furan-2-carboxylate | HCID 14945157 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-Amino-thiazol-4-yl)-furan-2-carboxylic acid methyl ester | HCID 86616435 | — |
Reaction Steps
5-(2-Bromo-acetyl)-furan-2-carboxylic acid methyl ester (0.39 g, 1.61 mmol) was treated with NaOAc (0.185 g, 2.25 mmol) and thiourea (0.12 g, 1.6 mmol) in EtOH to give 5-(2-Amino-thiazol-4-yl)-furan-2-carboxylic acid methyl ester; MS: 225.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595398B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-eeceb7f1539a46c0ae78d0b7f1e6cd1e |
| Source note | uspto-grants-2009_09 |