HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 57849879, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86616438 | HCID 86616438 | — |
| Product | HCID 57849879 | HCID 57849879 | — |
Reaction Steps
From (S)-2-[5-(4-carboxy-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester (Compound 5353, Example 353, 0.04 g, 0.09 mmol), HATU (0.044 g, 0.12 mmol), and (0.03 mL, 0.36 mmol) of cyclopropylamine using General Procedure 3F. 1HNMR (DMSO-d6) δ(ppm)12.44-12.42 (d, 1H), 8.43 (s, 1H), 7.99-7.65 (m, 5H), 7.35-7.10 (m, 4 H), 5.06-4.89 (m, 2H), 4.5-4.46 (m, 1H), 2.83 (s, 2H), 2.25 (m, 1H), 1.91 (m, 3H), 0.70-0.57, (m, 4H); MS: 491.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595398B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-7d91a35819134fa5bf63cc14af05c3db |
| Source note | uspto-grants-2009_09 |