Sodium Acetate → 4-(2-Amino-thiazol-4-yl)-N-cyclopentyl-benzenesulfonamide

HRID 737194Notes

Reaction equation

HRID 737194 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][CH:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=O.[NH2:20][C:21]([NH2:23])=[S:22].CC([O-])=O.[Na+]>CCO>[NH2:23][C:21]1[S:22][CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([S:11]([NH:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)(=[O:13])=[O:12])=[CH:7][CH:6]=2)[N:20]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 866164394-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide

Product 1

HCID 866164404-(2-Amino-thiazol-4-yl)-N-cyclopentyl-benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide (150 mg, 0.43 mmol) was combined with thiourea (33 mg, 0.43 mmol) in 7 ml of dry EtOH. To this solution was added NaOAc (53 mg, 0.65 mmol). Reaction mixture was stirred at room temperature for 4 hours. Reaction mixture was evaporated to dryness and used in the next step without further purification.

Workup

  1. customReaction mixture
  2. customReaction mixture
  3. customwas evaporated to dryness
  4. customused in the next step without further purification

Sources & evidence

ORD record
ord-e21784417c9c4729b6dea077530b1a9f
Source dataset
uspto-grants-2009_09
Patent number
US07595398B2

Reaction notes

Loading…