HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 57849761, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86616441 | HCID 86616441 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57849761 | HCID 57849761 | — |
| Product | HCID 86616443 | HCID 86616443 | — |
Reaction Steps
A mixture of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester (0.38 g, 1.52 mmol), HATU (0.58 g, 1.52 mmol)), and DIEA (0.4 mL, 3.0 mmol) in DMF (16 mL) was stirred at room temperature for 1 h. 6-(2-Amino-thiazol-4-yl)-nicotinic acid benzyl ester (0.32 g, 1.0 mmol) was added and the reaction mixture was heated to 50° C. for 48 h. The crude product was purified by reverse phase HPLC to furnish the desired product 6-{2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-thiazol-4-yl}-nicotinic acid benzyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595398B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-70635dc3b73d46bc91ed116dd182ba4d |
| Source note | uspto-grants-2009_09 |