HCID 86616438, compound → HCID 86616444, compound

HRID 737197Notes

Reaction equation

HRID 737197 reaction equation
C([O:8][C:9](=[O:39])[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:17]=[C:18]([NH:21][C:22]([C@@H:24]3[CH2:28][CH2:27][CH2:26][N:25]3[C:29]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[O:30])=[O:23])[S:19][CH:20]=2)=[N:12][CH:11]=1)C1C=CC=CC=1.C(OC(N1CCC[C@H]1C(=O)NC1SC(C2C=CC(C(O)=O)=CC=2)=CN=1)=O)C1C=CC=CC=1>>[CH2:32]([O:31][C:29]([N:25]1[CH2:26][CH2:27][CH2:28][C@H:24]1[C:22]([NH:21][C:18]1[S:19][CH:20]=[C:16]([C:13]2[CH:14]=[CH:15][C:10]([C:9]([OH:39])=[O:8])=[CH:11][N:12]=2)[N:17]=1)=[O:23])=[O:30])[C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 86616438HCID 86616438, compoundHCID 86616443HCID 86616443, compound

Product 1

HCID 86616444HCID 86616444, compound

Procedure

Hydrolysis of 6-{2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-thiazol-4-yl}-nicotinic acid benzyl ester (0.075 g, 0.14 mmol) similar to the procedure described for the synthesis of Compound 5353 (Example 353), gave 6-{2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-thiazol-4-yl}-nicotinic acid.

Sources & evidence

ORD record
ord-f5b4c4707aac457792d4453c39e1d1af
Source dataset
uspto-grants-2009_09
Patent number
US07595398B2

Reaction notes

Loading…