Trifluoroacetic acid methylene chloride → HCID 57849719, compound

Participants

Reaction Steps

4-(4-{2-[(1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-thiazol-4-yl}-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester (Compound 5336 Example 336 100 mg, 0.16 mmol) was dissolved in 4 mL of 1:1 solution of CH2Cl2/TFA and stirred for 1.5 at room temperature. The reaction mixture was evaporated under reduced pressure to give pure desired product. MS: 534.2(M+H+); H1 NMR (MeOH-d4): δ(ppm) (HCl salt) 7.99 (m, 4H), 7.28 (m, 3H), 7.12 (d, 1H), 7.00 (d, 2H), 5.02 (m, 2H), 4.56 (m, 2H), 4.19 (m, 1H), 3.69 (m, 1H), 3.55 (m, 4H), 3.17 (t, 2H), 2.16 (m, 1H), 2.11 (m, 4H), 1.92 (m, 4H).

Provenance & Evidence