HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Amino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-tert-Butoxycarbonylamino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester | HCID 86616446 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Amino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester | HCID 86616445 | — |
Reaction Steps
A mixture of 2-tert-Butoxycarbonylamino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester (0.28 g, 6.71 mmol) and TFA (5 mL) in dichloromethane (5 mL) was stirred at room temperature for 2 h. The mixture was concentrated in vacuo to give 2-Amino-4-(4-cyclopropylcarbamoyl-phenyl)-thiazole-5-carboxylic acid methyl ester; MS: 417.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595398B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f0b67a365fbf486e830e0c7007fe3db9 |
| Source note | uspto-grants-2009_09 |