Dimethylformamide → HCID 59140918, compound

Participants

Reaction Steps

2-[4-(2-carboxy-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester (General Procedure 3A, 125 mg, 0.28 mmol) was dissolved in 4 mL of DMF. To this solution was added HATU (160.9 mg, 0.42 mmol) and DIEA (0.05 mL, 0.36 mmol). This solution was stirred at room temperature for 1 hour. To this solution was added 56.3 mg of 3-amino-piperidine-1-carboxylic acid-tert-butyl ester. Reaction mixture was stirred overnight at room temperature, and then purified using reverse phase HPLC. MS: 634.3 (M+H+); H1 NMR (DMSO-d6): δ(ppm) 12.48 (s, 1H), 8.10 (m, 5H), 7.36 (br s, 2H), 7.08 (m, 3H), 5.01 (m, 2H), 4.43 (m, 2H), 3.80-3.50 (m, 4H), 2.81 (m, 2H), 2.23 (m, 2H), 1.93 (m, 5H), 1.29 (s, 9H).

Provenance & Evidence