HCID 57849864, compound → HCID 57849811, compound

HRID 737210Notes

Reaction equation

BrCC(C1C=CC(S(NC2CC2)(=O)=O)=CC=1)=O.[CH2:18]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH2:30][CH:29]1[C:33](=[O:55])[NH:34][C:35]1[S:36][CH:37]=[C:38]([C:40]2[CH:45]=[CH:44][C:43]([S:46](=[O:54])(=[O:53])[NH:47][CH:48]3[CH2:52]CC[CH2:49]3)=[CH:42][CH:41]=2)[N:39]=1)=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]([N:28]1[CH2:32][CH2:31][CH2:30][CH:29]1[C:33](=[O:55])[NH:34][C:35]1[S:36][CH:37]=[C:38]([C:40]2[CH:45]=[CH:44][C:43]([S:46](=[O:53])(=[O:54])[NH:47][CH:48]3[CH2:52][CH2:49]3)=[CH:42][CH:41]=2)[N:39]=1)=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 57849864HCID 57849864, compound

HCID 86616448HCID 86616448, compound

Product 1

HCID 57849811HCID 57849811, compound

Procedure

Synthesized from 4-(2-bromo-acetyl)-N-cyclopropyl-benzenesulfonamide (150 mg, 0.57 mmol) following multi-step procedure for Example 354 (Compound 5354). MS: 527.1 (M+H+); H1 NMR (MeOH-d4): δ(ppm) 8.18 (dd, 2H), 7.91 (dd, 2H), 8.03 (d, 1H), 7.28 (m, 2H), 7.11 (m, 2H), 5.09 (m, 2H), 3.48 (m, 1H), 2.76 (m, 2H), 2.98 (m, 3H), 1.29 (m, 1H), 0.51 (brs, 1H).

Sources & evidence

ORD record: ord-e254abafc02c4c3ba489e653e1da8763
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595398B2

Reaction notes

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