Sodium borohydride → HCID 59009442, compound

Participants

Reaction Steps

2-[4-(4-Cyano-phenyl)-thiazol-2-ylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester (100 mg, 0.23 mmol) was suspended in 10 mL of dry EtOH. To this suspension was added NaBH4 (12.8 mg, 0.46 mmol) followed by CoCl2 (60 mg, 0.46 mmol). Reaction mixture was stirred at room temperature for 4 hours. Reaction mixture was filtered and filtrate concentrated under reduced pressure to yield crude product which was then purified using reverse phase HPLC. MS: 433.1 (M+H+); H1 NMR (MeOH-d4): δ(ppm) 8.00 (d, 2H), 7.49 (m, 3H), 7.37 (m, 2H), 7.18 (d, 1H), 7.02 (m, 2H), 5.03 (m, 2H), 4.49 (m, 1H), 4.16 (s, 2H), 3.96 (m, 2H), 3.61 (m, 2H), 2.39 (m, 1H), 1.99 (m, 4H).

Provenance & Evidence