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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737294Generated: October 30, 2026

4-Bromoanisole → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/737294

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromoanisoleHCID 7730—
Reactantp-ToluidineHCID 7813—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
ReagentIsoxazole, 5-phenyl-HCID 136800—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 114358283.123%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-32b5b587faf740c8af7e79b6bbbbc1a2
Source noteAhneman