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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737308Generated: October 25, 2026

p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/737308

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant4-ChloroanisoleHCID 12167—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
Reagent3-Methylisoxazole-5-carboxylic acid ethyl esterHCID 10329487—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 114358280%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-cbec00263f364becb3c9a5c9b75d9573
Source noteAhneman