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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737342Generated: October 29, 2026

p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

https://huagongshe.com/reaction/737342

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant1-Bromo-4-ethylbenzeneHCID 15313—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
Reagent3-Methylisoxazole-5-carboxylic acid ethyl esterHCID 10329487—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-ethyl-N-(4-methylphenyl)anilineHCID 2081671235.871%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-fa28d7e7f531476692260dfa7b1275f3
Source noteAhneman