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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737366Generated: October 28, 2026

p-Toluidine → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/737366

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentEthyl 5-methylisoxazole-3-carboxylateHCID 76677—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 1871279938.917%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-366806997db74cc1b03f4346272fa2a6
Source noteAhneman