Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737370Generated: October 31, 2026

p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/737370

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant4-IodoanisoleHCID 69676—
ReagentEthyl 5-methylisoxazole-3-carboxylateHCID 76677—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 1143582819.596%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-c3ba16c2c5b34058b8237afa9c03e335
Source noteAhneman