Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737445Generated: October 30, 2026

p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/737445

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant4-IodoanisoleHCID 69676—
ReagentIsoxazole, 5-phenyl-HCID 136800—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 1143582821.977%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-52b538e0bb864d9bb1bc701553644127
Source noteAhneman