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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737529Generated: October 30, 2026

p-Toluidine → 3-Pyridinamine, N-(4-methylphenyl)-

https://huagongshe.com/reaction/737529

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant3-IodopyridineHCID 70714—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
Reagent3-Methylisoxazole-5-carboxylic acid ethyl esterHCID 10329487—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product3-Pyridinamine, N-(4-methylphenyl)-HCID 60358994.691%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-b6281c5997f94269aa19a4dd56d6731c
Source noteAhneman