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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 73763생성일: 2026년 10월 25일

(3S)-3-Pyrrolidinemethanol → (S)-5-bromo-N-(3-fluoro-4-(trifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide

https://huagongshe.com/reaction/73763

반응식

참여 물질

역할이름HCID투입량
반응물(3S)-3-PyrrolidinemethanolHCID 7446911—
반응물5-bromo-6-chloro-N-(3-fluoro-4-(trifluoromethoxy)phenyl)nicotinamideHCID 86702608—
생성물(S)-5-bromo-N-(3-fluoro-4-(trifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamideHCID 86702609—

반응 단계

The title compound was prepared in an analogous fashion to that described in Stage 9.2 using 5-bromo-6-chloro-N-(3-fluoro-4-(trifluoromethoxy)phenyl)nicotinamide (Stage 13.3) and (S)-1-pyrrolidin-3-yl-methanol to afford an off-white crystalline solid. HPLC (Condition 4) tR=5.99 min, UPLC-MS (Condition 3) tR=1.18 min, m/z=478.1/480.1 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08829195B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-b000417e0e2c437ebf737ce3b3ed8475
출처 메모uspto-grants-2014_09