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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737636Generated: October 30, 2026

p-Toluidine → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/737636

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentIsoxazole, 5-phenyl-HCID 136800—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 1871279925.835%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-f95bfa29926a49a091edc24b8f6c9c53
Source noteAhneman